2-Dimethylaminoethanol
Scientific Name: DMAE
Other Names: 2-Dimethyl aminoethanol, Deaner, Deanol, Dimethylaminoethanol, Dimethylethanolamine
Should I take it?
Between 1957 and 1983, DMAE was sold in the U.S. as a prescription drug named Deaner or Deanol. Several small studies--mostly conducted from the 1950s through the 1970s--tested it as a possible treatment for attention-deficit hyperactivity disorder (ADHD). Although DMAE appeared to improve learning and behavior, newer more effective drugs were being developed and approved. Some parents of children with autism also have reported improved behavior and/or concentration when their children took DMAE, but no scientific studies proves these results.
In the early 1980s, prescription DMAE was taken off the U.S. market after the FDA asked the manufacturers to do more extensive clinical studies to prove its effectiveness and safety. The manufacturers chose to stop making the pharmaceutical product rather than spend large amounts of time and money on trials. DMAE is still available in the United States as a dietary supplement, although it is not recognized by the U.S. Food and Drug Administration as a food additive. In Europe and Asia, a combination product (known as centrophenoxine or meclofenoxate) that includes DMAE is used as a memory enhancer.
In industry, DMAE is used in corrosion preventers, dyes, and paint removers. It helps to set plastics such as polyurethane and to dissolve pigments for water-based paints and coatings such as latex paint. DMAE is also used in anti-aging cosmetic products.
Dosage and Administration
Note: Alzheimer's disease, tardive dyskinesia, ADHD, and autism are very serious conditions that require the attention of a healthcare professional. They should not be self-treated. Neither DMAE nor any other supplement, herbal, or over-the-counter medication is sufficient treatment.
Recommendations for oral doses of DMAE vary widely--averaging 100 mg to 500 mg per day for adults, but reaching 1,600 mg (1.6 grams) per day in some clinical studies. Best absorbed when it is taken with food, DMAE may be taken in one dose or several doses per day. It is often included in combination products along with ginkgo and other natural products that may have memory-enhancing effects. Individuals who decide to take a product containing DMAE should follow the directions on the package that is purchased.
Topically, a gel containing 3% DMAE has been applied once daily to reduce facial lines and wrinkles.
Summary
Formerly a prescription drug for treating attention and behavior problems in children, DMAE is now a dietary supplement in the United States. It has been claimed, but not proven, to reduce aging, dementia, memory loss, and movement disorders. Topically, it may help to reduce the signs of aging on skin.
Risks
DMAE may worsen some mental disorders or epilepsy. Because it is known to damage developing animals, it should not be taken during pregnancy. It may also increase blood levels of homocysteine, possibly contributing to heart disease.
Side Effects
Taking DMAE has been associated with small increases in blood pressure, unpleasant body odor, gastrointestinal upset, mental changes, muscle cramps, and sleep disturbances. Individuals taking it may remember dreams better and may be able to tell they are dreaming while still asleep.
Interactions
DMAE may interfere with the effects of anticholinergic drugs and antipsychotic drugs. It may increase the effects and potential side effects of drugs and supplements that increase choline levels.
Updated August 29, 2007
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Should I take it? 
